

Malocclusion seems to be a frequent dental anomaly that typically develops during childhood as a dental malalignment or inappropriate relationship with the dental arches. More randomized controlled trials are critically needed to safely make an evidence-based treatment conclusion.

The current evidence demonstrated that nonextraction protocols for orthodontic treatment are a safe and effective alternative to extraction protocols individually tailored treatment strategies should be applied. On the other hand, the extraction method significantly increased the ANB compared with the nonextraction group (, 95% CI: 0.25, 1.31 ). Between April 30 th and November 30 th, 2020, we searched PubMed and SCOPUS for published papers from inception to November 2020 using “orthodontic,” “extraction,” “nonextraction,” and “Malocclusion.” Included studies were summarized, and relevant data were extracted and analyzed using Review Manager 5.4. nonextraction in orthodontic treatment on patients’ soft-tissue profile with malocclusion. We aimed to summarize the current evidence regarding the impact of extraction vs.
